RECENT CHEMICAL INVESTIGATIONS OF BACTERIAL TOXINS
نویسندگان
چکیده
منابع مشابه
Recent Chemical Investigations of Bacterial Toxins.
Part I. The Production of Bacterial Toxins .. 4 1. The use of media of simplified composition.......................... 4 2. The possible relationship of oxidation-reduction systems to the formation of toxins............................................. 6 3. Other factors affecting the formation of toxins .......... .......... 8 4. Toxins as products of secretion, autolysis, or the action of en...
متن کاملGeneral aspects and recent advances on bacterial protein toxins.
Bacterial pathogens produce protein toxins to influence host-pathogen interactions and tip the outcome of these encounters toward the benefit of the pathogen. Protein toxins modify host-specific targets through posttranslational modifications (PTMs) or noncovalent interactions that may inhibit or activate host cell physiology to benefit the pathogen. Recent advances have identified new PTMs and...
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Many bacterial toxins are proteins, encoded by the bacterial chromosomal genes, plasmids or phages. Lysogenic phages form part of the chromosome. The toxins are usually liberated from the organism by lysis, but some are shed with outer membrane proteins in outer membrane vesicles. An important non-protein toxin is lipopolysaccharide or endotoxin, which is a constituent of the cell wall of gram ...
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Protease domains within toxins typically act as the primary effector domain within target cells. By contrast, the primary function of the cysteine protease domain (CPD) in Multifunctional Autoprocessing RTX-like (MARTX) and Clostridium sp. glucosylating toxin families is to proteolytically cleave the toxin and release its cognate effector domains. The CPD becomes activated upon binding to the e...
متن کاملBTXpred: Prediction of Bacterial Toxins
This paper describes a method developed for predicting bacterial toxins from their amino acid sequences. All the modules, developed in this study, were trained and tested on a non-redundant dataset of 150 bacterial toxins that included 77 exotoxins and 73 endotoxins. Firstly, support vector machines (SVM) based modules were developed for predicting the bacterial toxins using amino acids and dip...
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ژورنال
عنوان ژورنال: Bacteriological Reviews
سال: 1938
ISSN: 0005-3678
DOI: 10.1128/br.2.1.3-45.1938